An example of an entry to Depressing Comics Week.

Depressing Comics Week is a reoccurring special where for an entire week, explosm removes the humor from the Cyanide and Happiness comics and shorts leaving behind the most depressing comics explosm could think of covering realistic topics such as: unexpected death, cancer, war, human trafficking, child abuse, suicide, and slavery.

Despite it's divergence from the typical style of Cyanide and Happiness comics, Depressing Comics are rather popular amongst fans.