The plot of Cyanide & Happiness-Dogs is a dog who was looking for food behind a resturant called Fellatio's when the resturant owner throws out rotten spaghetti. The dog begins to eat when a female dog shows up to eat too. The dog and female dog begin to eat when suddenly a hobo comes up and kick the female dog. He begins eating the spaghetti, then he looks at the dog before running away and taking the female dog with him.
After the credits, the hobo kicks the dog while the female dog is on the hobo's head as a hat.
- This is a obvious parody of The Lady and The Tramp.